Here the Human Pangenome Reference Consortium presents a first draft of the human
pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of …

Existing human genome assemblies have almost entirely excluded repetitive sequences
within and near centromeres, limiting our understanding of their organization, evolution, and …

The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

The human reference genome is the most widely used resource in human genetics and is
due for a major update. Its current structure is a linear composite of merged haplotypes from …

Human centromeres have been traditionally very difficult to sequence and assemble owing
to their repetitive nature and large size 1 . As a result, patterns of human centromeric …

There has been tremendous progress in phased genome assembly production by combining
long-read data with parental information or linked-read data. Nevertheless, a typical …

Forty years of classical biochemical analysis have identified the molecular players involved
in initiation of transcription by eukaryotic RNA polymerase II (Pol II) and largely assigned …

The human pangenome, a new reference sequence, addresses many limitations of the current
GRCh38 reference. The first release is based on 94 high-quality haploid assemblies from …

Previous studies have paid little attention to either the development or sexual dimorphism of
masticatory performance. The aim of this study was to measure and compare the …

This paper updates results of an international study aimed at quantifying the links between
transport disadvantage (TD), social exclusion (SE) and well-being (WB) in Melbourne, …