[PDF][PDF] A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation
…, A Bhatta, SA Schattgen, JD McGowan, J Blin… - Cell, 2016 - cell.com
Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression.
Although lincRNAs are expressed in immune cells, their functions in immunity are largely …
Although lincRNAs are expressed in immune cells, their functions in immunity are largely …
[HTML][HTML] Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins
Programmable nucleases have enabled rapid and accessible genome engineering in
eukaryotic cells and living organisms. However, their delivery into target cells can be technically …
eukaryotic cells and living organisms. However, their delivery into target cells can be technically …
[HTML][HTML] Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
M Eshraghi, PP Karunadharma, J Blin… - Nature …, 2021 - nature.com
The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …
A mitochondrial micropeptide is required for activation of the Nlrp3 inflammasome
…, M Atianand, Z Jiang, J Crabtree, J Blin… - The Journal of …, 2020 - journals.aai.org
Functional peptides encoded by short open reading frames are emerging as important
mediators of fundamental biological processes. In this study, we identified a micropeptide …
mediators of fundamental biological processes. In this study, we identified a micropeptide …
[HTML][HTML] PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma
(ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. …
(ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. …
Perspective: The RNA exosome, cytokine gene regulation and links to autoimmunity
J Blin, KA Fitzgerald - Cytokine, 2015 - Elsevier
The RNA exosome is a highly conserved exoribonuclease complex that is involved in RNA
processing, quality control and turnover regulation. The exosome plays pleiotropic functions …
processing, quality control and turnover regulation. The exosome plays pleiotropic functions …
[HTML][HTML] RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells
…, F Bourdelais, B Bennychen, J Blin-Gonthier… - Nature …, 2023 - nature.com
Embryonic stem cell (ESC) fate decisions are regulated by a complex circuitry that
coordinates gene expression at multiple levels from chromatin to mRNA processing. Recently, …
coordinates gene expression at multiple levels from chromatin to mRNA processing. Recently, …
Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation protein
M Eshraghi, P Karunadharma, J Blin, N Shahani… - BioRxiv, 2019 - biorxiv.org
The regulators that stall ribosome translocation are poorly understood. We find that
polyglutamine-expanded mutant Huntingtin (mHtt), the Huntington’s disease (HD) causing protein, …
polyglutamine-expanded mutant Huntingtin (mHtt), the Huntington’s disease (HD) causing protein, …
Efficient genome editing in primary cells and in vivo using viral-derived “Nanoblades” loaded with Cas9/sgRNA ribonucleoproteins
Programmable nucleases have enabled rapid and accessible genome engineering in
eukaryotic cells and living organisms. However, their delivery into target cells can be technically …
eukaryotic cells and living organisms. However, their delivery into target cells can be technically …
An intimate look at the viral replication cycle through ribosome profiling
J Blin, EP Ricci - Medecine Sciences: M/S, 2016 - europepmc.org
Next Generation Sequencing (NGS) techniques have revolutionized most biomedical
research fields over the past decade by allowing a broader vision on biological processes that …
research fields over the past decade by allowing a broader vision on biological processes that …