X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
…, C Günther, C Schmidt, R Schubert, H Han, J Boger… - Science, 2021 - science.org
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
suffering. To date, no effective drug is available to directly treat the disease. In a search for …
N‐terminomics for the identification of in vitro substrates and cleavage site specificity of the SARS‐CoV‐2 main protease
T Koudelka, J Boger, A Henkel, R Schönherr… - …, 2021 - Wiley Online Library
The genome of coronaviruses, including SARS‐CoV‐2, encodes for two proteases, a
papain like (PL pro ) protease and the so‐called main protease (M pro ), a chymotrypsin‐like …
papain like (PL pro ) protease and the so‐called main protease (M pro ), a chymotrypsin‐like …
[HTML][HTML] Rapid screening of in cellulo grown protein crystals via a small-angle X-ray scattering/X-ray powder diffraction synergistic approach
…, CM Jeffries, CE Blanchet, J Boger… - Journal of applied …, 2020 - scripts.iucr.org
Crystallization of recombinant proteins in living cells is an exciting new approach for
structural biology that provides an alternative to the time-consuming optimization of protein …
structural biology that provides an alternative to the time-consuming optimization of protein …
[HTML][HTML] A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst
R Schönherr, J Boger, JM Lahey-Rudolph… - Nature …, 2024 - nature.com
With the advent of serial X-ray crystallography on microfocus beamlines at free-electron
laser and synchrotron facilities, the demand for protein microcrystals has significantly risen in …
laser and synchrotron facilities, the demand for protein microcrystals has significantly risen in …
[HTML][HTML] A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip
B Norton-Baker, P Mehrabi, J Boger… - … Section D: Structural …, 2021 - scripts.iucr.org
Fixed-target serial crystallography has become an important method for the study of protein
structure and dynamics at synchrotrons and X-ray free-electron lasers. However, sample …
structure and dynamics at synchrotrons and X-ray free-electron lasers. However, sample …
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
…, C Günther, C Schmidt, R Schubert, H Han, J Boger… - 2020 - xfel.tind.io
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health
problems and economical challenges for mankind. To date, no effective drug is available to …
problems and economical challenges for mankind. To date, no effective drug is available to …
InCellCryst-A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins
R Schoenherr, J Boger, JM Lahey-Rudolph, M Harms… - bioRxiv, 2023 - biorxiv.org
With the advent of serial X-ray crystallography on microfocus beamlines at free-electron
laser and synchrotron facilities, the demand for protein microcrystals has significantly risen in …
laser and synchrotron facilities, the demand for protein microcrystals has significantly risen in …
Massive X-ray screening reveals two allosteric drug binding sites of SARS-CoV-2 main protease
…, C Günther, C Schmidt, R Schubert, H Han, J Boger… - bioRxiv, 2020 - biorxiv.org
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health
problems and economical challenges for mankind. To date, no effective drug is available to …
problems and economical challenges for mankind. To date, no effective drug is available to …
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2 (preprint)
…, C Guenther, C Schmidt, R Schubert, H Han, J Boger… - 2020 - pesquisa.bvsalud.org
Background: SARS-CoV-2, a novel coronavirus, and the etiologic agent for the current global
health emergency, causes acute infection of the respiratory tract leading to severe disease …
health emergency, causes acute infection of the respiratory tract leading to severe disease …
Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerase (PARP), blocks replication of the SARS-CoV-2 human coronavirus in vitro.(preprint)
…, C Guenther, C Schmidt, R Schubert, H Han, J Boger… - 2020 - pesquisa.bvsalud.org
By late 2020, the coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 has
caused tens of millions of infections and over 1 million deaths worldwide. A protective vaccine …
caused tens of millions of infections and over 1 million deaths worldwide. A protective vaccine …