Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels,
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in …

To the Editor: Eradication of the human immunodeficiency virus (HIV) is a difficult goal to
achieve, because a reservoir of replication-competent HIV is established in resting CD4 T …

Hydroxyurea, a drug widely used in therapy of several human diseases, inhibits deoxynucleotide
synthesis—and, consequently, DNA synthesis—by blocking the cellular enzyme …

Human immunodeficiency virus (HIV) vaccines have the potential to improve antiretroviral
drug treatment by inducing cytotoxic killing of HIV-infected cells. Prophylactic vaccines utilize …

In a randomized controlled trial with acute simian immunodeficiency virus (SIV)–infected
macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule …

Background The GIHU004 study was designed to evaluate the safety and immunogenicity
of three doses of DermaVir immunization in HIV-infected subjects on fully suppressive …

Combination antiretroviral therapy (cART) successfully suppresses HIV replication. However,
daily and lifelong treatment is necessary to manage patient illness because cART neither …

Background: HIV-specific cellular immune responses are associated with control of viremia
and delayed disease progression. An effective therapeutic vaccine could mimic these effects …

The antiviral activity of antisense oligodeoxynucleotide phosphorothioates complementary to
the tat gene, the gag mRNA, and the rev mRNA were studied in a long-term infection model…

Data from basic science and clinical studies suggest that hydroxyurea (hydroxycarbamide)-based
regimens are effective treatment options for patients with HIV at various stages of …