Mechanism of early dissemination and metastasis in Her2+ mammary cancer

…, MS Sosa, D Entenberg, H Hosseini, JF Cheung… - Nature, 2016 - nature.com
Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant 1 . Metastasis-initiating cells are …

[HTML][HTML] Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

…, PM Chen, KA Connolly, M Damo, JF Cheung… - Cell, 2021 - cell.com
CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal center (GC)
formation, but the importance of TFH-B cell interactions in cancer is unclear. We found …

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

…, JK Williams, AR Nobre, V Calvo, JF Cheung… - Nature cell …, 2017 - nature.com
Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear
how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we …

A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

…, E Fagerberg, I Monroy, A Hutchins, JF Cheung… - Science …, 2021 - science.org
“Stem-like” TCF1 + CD8 + T (T SL ) cells are necessary for long-term maintenance of T cell
responses and the efficacy of immunotherapy, but, as tumors contain signals that should drive …

Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2

…, E Risson, DK Singh, JS Di Martino, JF Cheung… - Nature Cancer, 2021 - nature.com
In the bone marrow (BM) microenvironment, where breast cancer (BC)-disseminated tumor
cells (DTCs) can remain dormant for decades, NG2 + /Nestin + mesenchymal stem cells (…

Application of value-driven design to commercial aeroengine systems

J Cheung, J Scanlan, J Wong, J Forrester, H Eres… - Journal of Aircraft, 2012 - arc.aiaa.org
DESIGN of aerospace systems is inherently complex, particularly with the emerging environmental
and economic concerns. By 2020, the Advisory Council for Aeronautics Research in …

IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory

…, HN Blackburn, E Sefik, JF Cheung… - Proceedings of the …, 2023 - National Acad Sciences
Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival,
and treatment options are limited. Antitumor immune memory plays a critical role in …

Inducible de novo expression of neoantigens in tumor cells and mice

…, Y Lu, M Nader, I William, JF Cheung… - Nature …, 2021 - nature.com
Inducible expression of neoantigens in mice would enable the study of endogenous antigen-specific
naïve T cell responses in disease and infection, but has been difficult to generate …

[PDF][PDF] 5-Azacytidine-and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

…, D Hasson, W Zheng, D Sun, X Huang, J Cheung… - Cell reports, 2023 - cell.com
Disseminated cancer cells (DCCs) in secondary organs can remain dormant for years to
decades before reactivating into overt metastasis. Microenvironmental signals leading to cancer …

Dimethylsulfone as a universal standard for analysis of organics by QNMR

RJ Wells, J Cheung, JM Hook - Accreditation and quality assurance, 2004 - Springer
Quantitative nuclear magnetic resonance (QNMR) is a primary analytical method which
allows the use of a standard not directly related to the target analyte. This could allow the …