Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic
disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in …

Background Treatment of dysplastic Barrett's oesophagus prevents progression to
adenocarcinoma; however, the optimal diagnostic strategy for Barrett's oesophagus is unclear. The …

The transition zone (TZ) ciliary subcompartment is thought to control cilium composition and
signalling by facilitating a protein diffusion barrier at the ciliary base. TZ defects cause …

Cilia have a unique diffusion barrier (“gate”) within their proximal region, termed transition
zone (TZ), that compartmentalises signalling proteins within the organelle. The TZ is known to …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

BACKGROUND: This paper describes a retrospective investigation of methicillin-resistant
Staphylococcus aureus (MRSA) acquisition in an 8-bed intensive care unit (ICU) over a 5-…

Mutations in genes encoding cilia proteins cause human ciliopathies, diverse disorders
affecting many tissues. Individual genes can be linked to ciliopathies with dramatically different …

Background: The utility of dairy ingredients in the supplementary foods used in the
treatment of childhood moderate acute malnutrition (MAM) remains unsettled. Objective: We …

Background Joubert syndrome (JBTS) and related disorders are defined by cerebellar
malformation (molar tooth sign), together with neurological symptoms of variable expressivity. The …

Primary cilia are specialised sensory and developmental signalling devices extending from
the surface of most eukaryotic cells. Defects in these organelles cause inherited human …