Africa is inferred to be the continent of origin for all modern human populations, but the details
of human prehistory and evolution in Africa remain largely obscure owing to the complex …

Here, Ruby et al. analyze an unprecedented amount of public family tree data from Ancestry
and determine that the heritability of human longevity was well below 10%, lower than the …

Assessing the extent of linkage disequilibrium (LD) in natural populations of a nonmodel
species has been difficult due to the lack of available genomic markers. However, with …

Approximately 15 genes have been directly associated with skin pigmentation variation in
humans, leading to its characterization as a relatively simple trait. However, by assembling a …

Despite strides in characterizing human history from genetic polymorphism data, progress in
identifying genetic signatures of recent demography has been limited. Here we identify very …

Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a
new host every second. While analyses of genetic data from natural populations of M.tb have …

Patterns of gene flow can have marked effects on the evolution of populations. To better
understand the migration dynamics of Mycobacterium tuberculosis, we studied genetic data from …

While hundreds of loci have been identified as reflecting strong-positive selection in human
populations, connections between candidate loci and specific selective pressures often …

We present a massive investigation into the genetic basis of human lifespan. Beginning with
a genome-wide association (GWA) study using a de-identified snapshot of the unique …

Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …