Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs
and proteins. Germ granules are present only within the germ cells of animals, including …

RNAi-related pathways regulate diverse processes, from developmental timing to
transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent …

In the formation of a complex organism and the differentiation of specific cell types, there are
often demands for high levels of particular gene products. These demands can be met by …

In metazoans, Piwi-related Argonaute proteins have been linked to germline maintenance,
and to a class of germline-enriched small RNAs termed piRNAs. Here we show that an …

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep-…

Chorion gene amplification in the ovaries of Drosophila melanogaster is a powerful system
for the study of metazoan DNA replication in vivo. Using a combination of high-resolution …

The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that
use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one …

Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms
to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that associate with …

In Caenorhabditis elegans, the Piwi-interacting small RNA (piRNA)-mediated germline
surveillance system encodes more than 30,000 unique 21-nucleotide piRNAs, which silence a …

Argonaute (AGO) proteins interact with distinct classes of small RNAs to direct multiple
regulatory outcomes. In many organisms, including plants, fungi, and nematodes, cellular RNA-…