CRISPR/Cas9 technology of genome editing has greatly facilitated the targeted inactivation
of genes in vitro and in vivo in a wide range of organisms. In zebrafish, it allows the rapid …

In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance: …

Long restricted to the field of developmental biology, the use of the zebrafish (Danio rerio)
has extended to the study of human pathogenesis. Fostered by the rapid adaptation of new …

INTRODUCTION The “cancerized field” concept posits that cells in a given tissue sharing an
oncogenic mutation are cancer-prone, yet only discreet clones within the field initiate tumors…

Inevitably fatal some 40 years, acute promyelocytic leukemia (APL) can now be cured in
more than 95% of cases. This clinical success story is tightly linked to tremendous progress in …

Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)–retinoic
acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling …

As the result of intense clinical and basic research, acute promyelocytic leukemia (APL) has
progressively evolved from a deadly to a curable disease. Historically, efforts aimed at …

Melanomas originating from mucosal surfaces have low mutation burden, genomic instability,
and poor prognosis. To identify potential driver genes, we sequenced hundreds of cancer-…

Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci,
most of which are not functionally characterized. Here we report an approach integrating …

Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult T cell
leukemia/lymphoma (ATL), a disease with dismal long-term prognosis. The HTLV-I transactivator…