Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

Insomnia is the second most prevalent mental disorder, with no sufficient treatment available.
Despite substantial heritability, insight into the associated genes and neurobiological …

Neuroticism is an important risk factor for psychiatric traits, including depression 1 , anxiety 2
, 3 , and schizophrenia 4 , 5 – 6 . At the time of analysis, previous genome-wide association …

With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia
have not converged on findings that can be confidently used for precise experimental …

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally.
Large-scale schizophrenia genetic studies have reported primarily on European ancestry …