The histone modifying enzymes (HME) represent particularly promising targets for the
development of alternatives to praziquantel, the only currently available drug to combat …

The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma
genus, depends on the intensive use of a single drug, praziquantel, which increases …

The discovery of the epigenetic regulation of gene expression has revolutionized both our
understanding of how genomes function and approaches to the therapy of numerous …

Schistosomiasis is a major neglected parasitic disease that affects more than 265 million
people worldwide and for which the control strategy consists of mass treatment with the only …

Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic
diseases and each requires new innovative treatments. Targeting essential parasite …

Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that represent
promising therapeutic targets for the treatment of numerous human diseases. Yet the …

Background The chemotherapy of schistosomiasis currently depends on the use of a single
drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating …

Schistosomiasis, caused by the parasitic flatworm Schistosoma mansoni and related species,
is a tropical disease that affects over 200 million people worldwide. A new approach for …

A promising means in the search of new small molecules for the treatment of schistosomiasis
(amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present …

Treatment and control of schistosomiasis relies on the only available drug, praziquantel, and
the search for alternative chemotherapeutic agents is therefore urgent. Egg production is …