User profiles for Julien Ochala
Julien OchalaVerified email at kcl.ac.uk Cited by 4549 |
Skeletal muscle: a brief review of structure and function
WR Frontera, J Ochala - Calcified tissue international, 2015 - Springer
Skeletal muscle is one of the most dynamic and plastic tissues of the human body. In humans,
skeletal muscle comprises approximately 40 % of total body weight and contains 50–75 % …
skeletal muscle comprises approximately 40 % of total body weight and contains 50–75 % …
Congenital myopathies: disorders of excitation–contraction coupling and muscle contraction
The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …
[HTML][HTML] Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially true for …
establishment and maintenance of these sizes remain poorly understood. This is especially true for …
Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise
High-intensity interval training (HIIT) is a time-efficient way of improving physical performance
in healthy subjects and in patients with common chronic diseases, but less so in elite …
in healthy subjects and in patients with common chronic diseases, but less so in elite …
Single skeletal muscle fiber elastic and contractile characteristics in young and older men
J Ochala, WR Frontera, DJ Dorer… - The Journals of …, 2007 - academic.oup.com
The current investigation was designed to: (a) assess the impact of aging on elastic
characteristics of single skeletal muscle fibers from young (N = 6) and older men (N = 6); and (b) …
characteristics of single skeletal muscle fibers from young (N = 6) and older men (N = 6); and (b) …
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms
J Ochala, AM Gustafson, ML Diez… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary Wasting and severely impaired function of skeletal muscle is frequently
observed in critically ill intensive care unit (ICU) patients, with negative consequences …
observed in critically ill intensive care unit (ICU) patients, with negative consequences …
Relationship between force and size in human single muscle fibres
LS Krivickas, DJ Dorer, J Ochala… - Experimental …, 2011 - Wiley Online Library
When the contractile properties of single muscle fibres are studied, force is typically normalized
by fibre cross‐sectional area and expressed as specific force. We studied a set of 2725 …
by fibre cross‐sectional area and expressed as specific force. We studied a set of 2725 …
Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy
…, BP Monia, M Bitoun, J Ochala… - Proceedings of the …, 2018 - National Acad Sciences
Centronuclear myopathies (CNM) are a group of severe muscle diseases for which no
effective therapy is currently available. We have previously shown that reduction of the large …
effective therapy is currently available. We have previously shown that reduction of the large …
[HTML][HTML] NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
…, H Granzier, J Ochala - Acta neuropathologica …, 2022 - Springer
Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle disorders.
NM is often associated with mutations in the NEB gene. Even though the exact NEB-NM …
NM is often associated with mutations in the NEB gene. Even though the exact NEB-NM …
Aberrant post‐translational modifications compromise human myosin motor function in old age
M Li, H Ogilvie, J Ochala, K Artemenko, H Iwamoto… - Aging cell, 2015 - Wiley Online Library
Novel experimental methods, including a modified single fiber in vitro motility assay, X‐ray
diffraction experiments, and mass spectrometry analyses, have been performed to unravel the …
diffraction experiments, and mass spectrometry analyses, have been performed to unravel the …