User profiles for Julien Ochala

Julien Ochala

Verified email at kcl.ac.uk
Cited by 4549

Skeletal muscle: a brief review of structure and function

WR Frontera, J Ochala - Calcified tissue international, 2015 - Springer
Skeletal muscle is one of the most dynamic and plastic tissues of the human body. In humans,
skeletal muscle comprises approximately 40 % of total body weight and contains 50–75 % …

Congenital myopathies: disorders of excitation–contraction coupling and muscle contraction

…, S Treves, F Zorzato, A Sarkozy, J Ochala… - Nature Reviews …, 2018 - nature.com
The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …

[HTML][HTML] Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

…, HF Dugdale, S Sadayappan, J Ochala… - Nature …, 2020 - nature.com
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially true for …

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise

…, M Brazaitis, AJ Cheng, J Ochala… - Proceedings of the …, 2015 - National Acad Sciences
High-intensity interval training (HIIT) is a time-efficient way of improving physical performance
in healthy subjects and in patients with common chronic diseases, but less so in elite …

Single skeletal muscle fiber elastic and contractile characteristics in young and older men

J Ochala, WR Frontera, DJ Dorer… - The Journals of …, 2007 - academic.oup.com
The current investigation was designed to: (a) assess the impact of aging on elastic
characteristics of single skeletal muscle fibers from young (N = 6) and older men (N = 6); and (b) …

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

J Ochala, AM Gustafson, ML Diez… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary Wasting and severely impaired function of skeletal muscle is frequently
observed in critically ill intensive care unit (ICU) patients, with negative consequences …

Relationship between force and size in human single muscle fibres

LS Krivickas, DJ Dorer, J Ochala… - Experimental …, 2011 - Wiley Online Library
When the contractile properties of single muscle fibres are studied, force is typically normalized
by fibre cross‐sectional area and expressed as specific force. We studied a set of 2725 …

Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

…, BP Monia, M Bitoun, J Ochala… - Proceedings of the …, 2018 - National Acad Sciences
Centronuclear myopathies (CNM) are a group of severe muscle diseases for which no
effective therapy is currently available. We have previously shown that reduction of the large …

[HTML][HTML] NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy

…, H Granzier, J Ochala - Acta neuropathologica …, 2022 - Springer
Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle disorders.
NM is often associated with mutations in the NEB gene. Even though the exact NEB-NM …

Aberrant post‐translational modifications compromise human myosin motor function in old age

M Li, H Ogilvie, J Ochala, K Artemenko, H Iwamoto… - Aging cell, 2015 - Wiley Online Library
Novel experimental methods, including a modified single fiber in vitro motility assay, X‐ray
diffraction experiments, and mass spectrometry analyses, have been performed to unravel the …