User profiles for Julien P. Duxin
 | Julien P. DuxinHarvard Medical School Verified email at hms.harvard.edu Cited by 1470 |
[PDF][PDF] Repair of a DNA-protein crosslink by replication-coupled proteolysis
DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and chemotherapeutic
agents and pose a severe threat to genome stability. We use Xenopus egg extracts to …
agents and pose a severe threat to genome stability. We use Xenopus egg extracts to …
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein
JP Duxin, B Dao, P Martinsson, N Rajala… - … and cellular biology, 2009 - Taylor & Francis
Dna2 is a highly conserved helicase/nuclease that in yeast participates in Okazaki fragment
processing, DNA repair, and telomere maintenance. Here, we investigated the biological …
processing, DNA repair, and telomere maintenance. Here, we investigated the biological …
[PDF][PDF] Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S …
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S …
What is the DNA repair defect underlying Fanconi anemia?
Fanconi anemia (FA) is a rare human genetic disease characterized by bone marrow failure,
cancer predisposition, and genomic instability. It has been known for many years that FA …
cancer predisposition, and genomic instability. It has been known for many years that FA …
[PDF][PDF] The CMG helicase bypasses DNA-protein cross-links to facilitate their repair
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network
KK Karanja, SW Cox, JP Duxin, SA Stewart… - Cell cycle, 2012 - Taylor & Francis
During DNA replication, stalled replication forks and DSBs arise when the replication fork
encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other …
encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other …
[PDF][PDF] The ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated
single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to …
single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to …
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat
to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and …
to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and …
[HTML][HTML] FEN1 ensures telomere stability by facilitating replication fork re-initiation
A Saharia, DC Teasley, JP Duxin, B Dao… - Journal of biological …, 2010 - ASBMB
Telomeres are terminal repetitive DNA sequences whose stability requires the coordinated
actions of telomere-binding proteins and the DNA replication and repair machinery. Recently, …
actions of telomere-binding proteins and the DNA replication and repair machinery. Recently, …
[HTML][HTML] A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination
Mutations in the tumour suppressor gene BRCA2 are associated with predisposition to
breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by …
breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by …