Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and
fusion, referred as ‘mitochondrial dynamics’, in order to maintain their shape, distribution and …

The mechanisms that link environmental and intracellular stimuli to mitochondrial functions,
including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well …

Hepatic metabolism requires mitochondria to adapt their bioenergetic and biosynthetic output
to accompany the ever-changing anabolic/catabolic state of the liver cell, but the wiring of …

Mitochondria are dynamic organelles involved in numerous physiological functions. Beyond
their function in ATP production, mitochondria regulate cell death, reactive oxygen species (…

The existence of the bcl-2 (B-cell lymphoma-2) gene was reported nearly 30years ago. Yet,
Bcl-2 family group of proteins still surprises us with their structural and functional diversity. …

Peroxisomes function together with mitochondria in a number of essential biochemical pathways,
from bile acid synthesis to fatty acid oxidation 1 . Peroxisomes grow and divide from pre…

Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma 1 . Loss of FH in the kidney elicits several oncogenic signalling cascades through the …

There has been evidence that mitochondrial fragmentation is required for apoptosis, but the
molecular links between the machinery regulating dynamics and cell death have been …

Mitochondrial plasticity is a key regulator of cell fate decisions. Mitochondrial division
involves Dynamin-related protein-1 (Drp1) oligomerization, which constricts membranes at …

INTRODUCTION Cytotoxic T lymphocytes (CTLs) are important cells within the immune
system that are able to recognize and destroy cancer and virally infected cells. Killing is …