[HTML][HTML] Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study

RG Jenkins, JK Simpson, G Saini… - The lancet Respiratory …, 2015 - thelancet.com
Background Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a
highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to …

[HTML][HTML] An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

TM Maher, E Oballa, JK Simpson, J Porte… - The Lancet …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable
disease trajectory. The aim of this study was to assess potential biomarkers to predict …

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis

…, G Azzopardi, M Grayer, JK Simpson… - European …, 2019 - Eur Respiratory Soc
Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a
role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is a …

[HTML][HTML] Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort

…, AMR Duggan, E Oballa, SC Taggart, JK Simpson… - Respiratory …, 2019 - Springer
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM)
deposition and remodelling. Measuring this activity provides an opportunity to develop tools …

[HTML][HTML] A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose …

TM Maher, JK Simpson, JC Porter, FJ Wilson… - Respiratory …, 2020 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with
poor prognosis and a significant unmet medical need. This study evaluated the safety, …

[HTML][HTML] Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants

…, PT Lukey, T Mant, S Parry, JK Simpson… - European journal of …, 2018 - Springer
Purpose Inhaled drug delivery is an attractive route by which to deliver drugs to lungs of
patients with idiopathic pulmonary fibrosis (IPF). GSK3008348 is a potent and selective small …

[HTML][HTML] The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis

…, S Yang, S Meah, E Oballa, JK Simpson… - Respiratory …, 2018 - Springer
Background Our aim was to investigate total and regional lung delivery of salbutamol in
subjects with idiopathic pulmonary fibrosis (IPF). Methods The TOPICAL study was a 4-period, …

[HTML][HTML] Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis

L Peix, IC Evans, DR Pearce, JK Simpson, TM Maher… - Scientific reports, 2018 - nature.com
Pulmonary fibrosis is a progressive scarring disorder of the lung with dismal prognosis and
no curative therapy. Clusterin, an extracellular chaperone and regulator of cell functions, is …

[HTML][HTML] Strategies for biomarker discovery in fibrotic disease

RP Marshall, JK Simpson, PT Lukey - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
The discovery and development of biomarkers for fibrotic diseases have potential utility in
clinical decision-making as well as in pharmaceutical research and development. This review …

Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles

S Chercheja, JK Simpson, HW Lam - Tetrahedron, 2011 - Elsevier
A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving
the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide…