The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Glutamine metabolism provides synergistic support for macrophage activation and elicitation
of desirable immune responses; however, the underlying mechanisms regulated by …

Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased NAD…

XCMS Online ( xcmsonline.scripps.edu ) is a cloud-based informatic platform designed to
process and visualize mass-spectrometry-based, untargeted metabolomic data. Initially, the …

Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in
colon cancer metabolism has been suggested but to date has not been evaluated. Using …

Although the objective of any ‘omic science is broad measurement of its constituents, such
coverage has been challenging in metabolomics because the metabolome is comprised of a …

Chronic inflammation triggers compensatory immunosuppression to stop inflammation and
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …

Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting
tumor progression in response to microenvironmental cues imposed by tumor and stromal …

An aim of systems biology is to understand complex interactions between genes, proteins
and metabolites by integrating and modeling multiple data sources. We report an'integrated-…