Accumulating data suggest that metastatic dissemination often occurs early during tumour
formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, …

Metastases arise from residual disseminated tumour cells (DTCs). This can happen years
after primary tumour treatment because residual tumour cells can enter dormancy and evade …

Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant 1 . Metastasis-initiating cells are …

Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via
growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by …

After dissemination from a primary tumor, cancer cells may resume growth, leading to overt
metastasis, or enter a state of protracted dormancy. However, mechanisms that determine …

We discovered that a shift between the state of tumorigenicity and dormancy in human
carcinoma (HEp3) is attained through regulation of the balance between two classical mitogen-…

In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow
(BM) while other organs (such as lung) present growing metastasis. This suggested that …

Patients with cancer can develop recurrent metastatic disease with latency periods that range
from years even to decades. This pause can be explained by cancer dormancy, a stage in …

The stress-activated kinase p38 plays key roles in tumor suppression and induction of tumor
cell dormancy. However, the mechanisms behind these functions remain poorly understood…