The study of how cells interact to produce tissue development, homeostasis, or diseases
was, until recently, almost purely experimental. Now, multi-cell computer simulation methods, …

A self-propelled particle model is introduced to study cell sorting occurring in some living
organisms. This allows us to evaluate the influence of intrinsic cell motility separately from …

Somitogenesis, the formation of the body's primary segmental structure common to all vertebrate
development, requires coordination between biological mechanisms at several scales. …

The formation of body segments (somites) in vertebrate embryos is accompanied by molecular
oscillations (segmentation clock). Interaction of this oscillator with a wave traveling along …

Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to
proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop …

Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions
generated by an active contractile process. Although the network components and their …

Cytoskeletal networks of actin filaments and myosin motors drive many dynamic cell processes.
A key characteristic of these networks is their contractility. Despite intense experimental …

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen
pharmacology and metabolism. We focus on a computational model to characterize whole body …

The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling
stem cells. The number and identity of these dividing and migrating stem cells are …

The intrinsic genetic program of a cell is not sufficient to explain all of the cell’s activities.
External mechanical stimuli are increasingly recognized as determinants of cell behavior. In the …