[HTML][HTML] Progress overview of bacterial two-component regulatory systems as potential targets for antimicrobial chemotherapy
H Hirakawa, J Kurushima, Y Hashimoto, H Tomita - Antibiotics, 2020 - mdpi.com
Bacteria adapt to changes in their environment using a mechanism known as the two-component
regulatory system (TCS) (also called “two-component signal transduction system” or “…
regulatory system (TCS) (also called “two-component signal transduction system” or “…
[HTML][HTML] Three New Integration Vectors and Fluorescent Proteins for Use in the Opportunistic Human Pathogen Streptococcus pneumoniae
LE Keller, AS Rueff, J Kurushima, JW Veening - Genes, 2019 - mdpi.com
Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for
use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed …
use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed …
Advances of genetic engineering in streptococci and enterococci
J Kurushima, H Tomita - Microbiology and Immunology, 2022 - Wiley Online Library
… and 22K07067 to Haruyoshi Tomita), the Naito Foundation to Jun Kurushima, Ohyama
Health Foundation Inc. to Jun Kurushima and GSK Japan research grant to Jun Kurushima. …
Health Foundation Inc. to Jun Kurushima and GSK Japan research grant to Jun Kurushima. …
[HTML][HTML] Roles of the Tol-Pal system in the Type III secretion system and flagella-mediated virulence in enterohemorrhagic Escherichia coli
…, K Suzue, A Takita, C Awazu, J Kurushima… - Scientific Reports, 2020 - nature.com
The Tol-Pal system is a protein complex that is highly conserved in many gram-negative
bacteria. We show here that the Tol-Pal system is associated with the enteric pathogenesis of …
bacteria. We show here that the Tol-Pal system is associated with the enteric pathogenesis of …
[PDF][PDF] Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq
…, R Aprianto, R Koning, A Domenech, J Kurushima… - Cell reports, 2022 - cell.com
Pneumolysin is a major virulence factor of Streptococcus pneumoniae that plays a key role
in interaction with the host during invasive disease. How pneumolysin influences these …
in interaction with the host during invasive disease. How pneumolysin influences these …
Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events
J Kurushima, N Campo, R van Raaphorst, G Cerckel… - Elife, 2020 - elifesciences.org
The spread of antimicrobial resistance and vaccine escape in the human pathogen Streptococcus
pneumoniae can be largely attributed to competence-induced transformation. Here, …
pneumoniae can be largely attributed to competence-induced transformation. Here, …
[HTML][HTML] The Type III Secreted Protein BspR Regulates the Virulence Genes in Bordetella bronchiseptica
Bordetella bronchiseptica is closely related with B. pertussis and B. parapertussis, the
causative agents of whooping cough. These pathogenic species share a number of virulence …
causative agents of whooping cough. These pathogenic species share a number of virulence …
Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades
…, S Kobayashi, Y Hirahara, J Kurushima… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Antimicrobial resistance (AMR) of bacterial pathogens, including enterococci, is a global
concern, and plasmids are crucial for spreading and maintaining AMR genes. Plasmids with …
concern, and plasmids are crucial for spreading and maintaining AMR genes. Plasmids with …
New colony multiplex PCR assays for the detection and discrimination of vancomycin-resistant enterococcal species
T Nomura, Y Hashimoto, J Kurushima… - Journal of …, 2018 - Elsevier
New colony multiplex PCR assays for detection of seven types of vancomycin-resistance
determinants and eight types of Enterococcus species were developed. For 135 enterococcal …
determinants and eight types of Enterococcus species were developed. For 135 enterococcal …
[HTML][HTML] Dissemination and genetic analysis of the stealthy vanB gene clusters of Enterococcus faecium clinical isolates in Japan
Y Hashimoto, J Kurushima, T Nomura, K Tanimoto… - BMC microbiology, 2018 - Springer
Background VanB-type vancomycin (VAN) resistance gene clusters confer VAN resistances
on Enterococcus spp. over a wide range of MIC levels (MIC = 4–1000 mg/L). However, the …
on Enterococcus spp. over a wide range of MIC levels (MIC = 4–1000 mg/L). However, the …