User profiles for Jun O. Liu
Jun O. LiuJohns Hopkins School of Medicine Verified email at jhu.edu Cited by 30865 |
[HTML][HTML] Recent advances in drug repositioning for the discovery of new anticancer drugs
Drug repositioning (also referred to as drug repurposing), the process of finding new uses of
existing drugs, has been gaining popularity in recent years. The availability of several …
existing drugs, has been gaining popularity in recent years. The availability of several …
Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP
Y Liu-Chittenden, B Huang, JS Shim… - Genes & …, 2012 - genesdev.cshlp.org
The Drosophila TEAD ortholog Scalloped is required for Yki-mediated overgrowth but is largely
dispensable for normal tissue growth, suggesting that its mammalian counterpart may be …
dispensable for normal tissue growth, suggesting that its mammalian counterpart may be …
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades,
its precise mechanism of action remains incompletely understood. The glutarimide portion of …
its precise mechanism of action remains incompletely understood. The glutarimide portion of …
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
A library of drugs that are in clinical trials or use was screened for inhibitors of hypoxia-inducible
factor 1 (HIF-1). Twenty drugs inhibited HIF-1-dependent gene transcription by >88% at …
factor 1 (HIF-1). Twenty drugs inhibited HIF-1-dependent gene transcription by >88% at …
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
HIF-1 is a heterodimeric transcription factor that mediates adaptive responses to hypoxia
and plays critical roles in cancer progression. Using a cell-based screening assay we have …
and plays critical roles in cancer progression. Using a cell-based screening assay we have …
[PDF][PDF] Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
In a screen of drugs previously tested in humans we identified itraconazole, a systemic
antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a …
antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a …
XPB, a subunit of TFIIH, is a target of the natural product triptolide
…, PS Miller, JF Kugel, JA Goodrich, JO Liu - Nature chemical …, 2011 - nature.com
Triptolide ( 1 ) is a structurally unique diterpene triepoxide isolated from a traditional Chinese
medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor …
medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor …
[PDF][PDF] Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin
Background: Angiogenesis, the formation of new blood vessels, is essential for tumor growth.
The inhibition of angiogenesis is therefore emerging as a promising therapy for cancer. …
The inhibition of angiogenesis is therefore emerging as a promising therapy for cancer. …
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
Using a cell-based reporter gene assay, we screened a library of drugs in clinical use and
identified the anthracycline chemotherapeutic agents doxorubicin and daunorubicin as potent …
identified the anthracycline chemotherapeutic agents doxorubicin and daunorubicin as potent …
A three-hybrid system for detecting small ligand–protein receptor interactions
EJ Licitra, JO Liu - Proceedings of the National Academy of …, 1996 - National Acad Sciences
Small ligand–receptor interactions underlie many fundamental processes in biology and
form the basis for pharmacological intervention of human diseases in medicine. We report …
form the basis for pharmacological intervention of human diseases in medicine. We report …