Clustered regularly interspaced short palindromic repeats (CRISPR)-mediated
manipulation of genomic information is becoming more versatile by combining nuclease-deficient …

Recoding—the repurposing of genetic codons—is a powerful strategy for enhancing
genomes with functions not commonly found in nature. Here, we report computational design, …

Close relations between leukoaraiosis detected by computed tomography or magnetic
resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied …

We analyzed the transcriptome of Escherichia coli K-12 by strand-specific RNA sequencing
at single-nucleotide resolution during steady-state (logarithmic-phase) growth and upon …

Migraine is the most common cause of recurrent headache among children and adolescents
resulting in missing of school and disabling their daily life. The purpose of this study is to …

A systematic search was performed for DNA-binding sequences of YgiP, an uncharacterized
transcription factor of Escherichia coli, by using the Genomic SELEX. A total of 688 YgiP-…

Dan is a transcription factor that regulates the ttd operon encoding tartrate dehydratase.
During anaerobic conditions, its copy number increases by 100-fold, making Dan an abundant …

The effects of nucleoid proteins Fis and Dps of Escherichia coli on the higher order structure
of a giant DNA were studied, in which Fis and Dps are known to be expressed mainly in the …

When the rate of production of metabolites in bacteria exceeds the amounts needed for cell
growth, excess metabolites are secreted into the extracellular environment. Upon entry into …

Understanding the functional information of all genes and the biological mechanism based
on the comprehensive genome regulation mechanism is an important task in life science. …