Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and …
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and …
Gut microbiota composition modifies fecal metabolic profiles in mice
The gut microbiome is known to be extensively involved in human health and disease. In
order to reveal the metabolic relationship between host and microbiome, we monitored …
order to reveal the metabolic relationship between host and microbiome, we monitored …
Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins
MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression at
the post-transcriptional level. To identify miRs that may regulate neuronal cell death after …
the post-transcriptional level. To identify miRs that may regulate neuronal cell death after …
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
Traumatic brain injury ( TBI ) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …
Described initially in boxers and currently recognized across high contact sports, the …
[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment: Involvement of cell cycle activation
Cognitive dysfunction has been reported in patients with spinal cord injury (SCI), but it has
been questioned whether such changes may reflect concurrent head injury, and the issue has …
been questioned whether such changes may reflect concurrent head injury, and the issue has …
Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways
Experimental spinal cord injury (SCI) causes chronic neuropathic pain associated with
inflammatory changes in thalamic pain regulatory sites. Our recent studies examining chronic …
inflammatory changes in thalamic pain regulatory sites. Our recent studies examining chronic …
Function and mechanisms of autophagy in brain and spinal cord trauma
Significance: Traumatic brain injury (TBI) and spinal cord injury (SCI) are major causes of
death and long-term disability worldwide. Despite important pathophysiological differences …
death and long-term disability worldwide. Despite important pathophysiological differences …
Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury
Delayed secondary biochemical and cellular changes after traumatic brain injury continue
for months to years, and are associated with chronic neuroinflammation and progressive …
for months to years, and are associated with chronic neuroinflammation and progressive …
High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats
…, F Hao, Y Duan, X Yan, Y Zhao, J Wu… - Journal of proteome …, 2013 - ACS Publications
Obesity is a condition resulting from the interactions of individual biology and environmental
factors causing multiple complications. To understand the system’s metabolic changes …
factors causing multiple complications. To understand the system’s metabolic changes …