[PDF][PDF] Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase,
which regulates protein translation, cell size, and autophagy. However, the amino acid …
which regulates protein translation, cell size, and autophagy. However, the amino acid …
[HTML][HTML] Glutamine reliance in cell metabolism
As knowledge of cell metabolism has advanced, glutamine has been considered an important
amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided …
amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided …
[PDF][PDF] A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, …
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, …
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation
p38 is associated with a macromolecular tRNA synthetase complex 1 . It has an essential
role as a scaffold for the complex, and genetic disruption of p38 in mice causes neonatal …
role as a scaffold for the complex, and genetic disruption of p38 in mice causes neonatal …
[PDF][PDF] Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia
Focal cortical dysplasia (FCD) is a major cause of the sporadic form of intractable focal
epilepsies that require surgical treatment. It has recently been reported that brain somatic …
epilepsies that require surgical treatment. It has recently been reported that brain somatic …
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis
MC Park, T Kang, D Jin, JM Han… - Proceedings of the …, 2012 - National Acad Sciences
Although adaptive systems of immunity against tumor initiation and destruction are well
investigated, less understood is the role, if any, of endogenous factors that have conventional …
investigated, less understood is the role, if any, of endogenous factors that have conventional …
[PDF][PDF] LysRS serves as a key signaling molecule in the immune response by regulating gene expression
Lysyl-tRNA synthetase (LysRS) was found to produce diadenosine tetraphosphate (Ap 4 A)
in vitro more than two decades ago. Here, we used LysRS silencing in mast cells in …
in vitro more than two decades ago. Here, we used LysRS silencing in mast cells in …
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein …
Mammalian methionyl-tRNA synthetase (MRS) plays an essential role in initiating translation
by transferring Met to initiator tRNA (tRNA i Met ). MRS also provides a cytosolic anchoring …
by transferring Met to initiator tRNA (tRNA i Met ). MRS also provides a cytosolic anchoring …
Lycorma delicatula (Hemiptera: Auchenorrhyncha: Fulgoridae: Aphaeninae) finally, but suddenly arrived in Korea
JM Han, H Kim, EJ Lim, S Lee… - Entomological …, 2008 - Wiley Online Library
A history of name changes in two fulgorid species –Lycorma delicatula and Limois emelianovi–
is reviewed. Lycorma delicatula was once mistakenly reported to occur in Korea. Now, it …
is reviewed. Lycorma delicatula was once mistakenly reported to occur in Korea. Now, it …
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA
synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive …
synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive …