User profiles for Jung-Un Park
 | Jung-Un ParkSt. Jude Children's Research Hospital Verified email at stjude.org Cited by 213 |
[HTML][HTML] Structures of the holo CRISPR RNA-guided transposon integration complex
CRISPR-associated transposons (CAST) are programmable mobile genetic elements that
insert large DNA cargos using an RNA-guided mechanism 1 , 2 – 3 . CAST elements contain …
insert large DNA cargos using an RNA-guided mechanism 1 , 2 – 3 . CAST elements contain …
Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense
AR VanderWal, JU Park, B Polevoda, JK Nicosia… - Science, 2023 - science.org
Type VI CRISPR-Cas systems use RNA-guided ribonuclease (RNase) Cas13 to defend
bacteria against viruses, and some of these systems encode putative membrane proteins that …
bacteria against viruses, and some of these systems encode putative membrane proteins that …
Mechanistic details of CRISPR-associated transposon recruitment and integration revealed by cryo-EM
CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided
DNA integration. Although structural data are known for nearly all core transposition …
DNA integration. Although structural data are known for nearly all core transposition …
Mechanism of target site selection by type VK CRISPR-associated transposases
CRISPR-associated transposases (CASTs) repurpose nuclease-deficient CRISPR effectors
to catalyze RNA-guided transposition of large genetic payloads. Type VK CASTs offer …
to catalyze RNA-guided transposition of large genetic payloads. Type VK CASTs offer …
Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition
CRISPR-associated transposons (CASTs) are natural RNA-directed transposition systems.
We demonstrate that transposon protein TniQ plays a central role in promoting R-loop …
We demonstrate that transposon protein TniQ plays a central role in promoting R-loop …
Structural basis for target site selection in RNA-guided DNA transposition systems
CRISPR-associated transposition systems allow guide RNA–directed integration of a single
DNA cargo in one orientation at a fixed distance from a programmable target sequence. We …
DNA cargo in one orientation at a fixed distance from a programmable target sequence. We …
Genome mining reveals high topological diversity of ω-ester-containing peptides and divergent evolution of ATP-grasp macrocyclases
ω-Ester-containing peptides (OEPs) are a family of ribosomally synthesized and post-translationally
modified peptides (RiPPs) containing intramolecular ω-ester or ω-amide bonds. …
modified peptides (RiPPs) containing intramolecular ω-ester or ω-amide bonds. …
CRISPR-Csx28 forms a Cas13b-activated membrane pore required for robust CRISPR-Cas adaptive immunity
AR VanderWal, JU Park, B Polevoda, EH Kellogg… - BioRxiv, 2021 - biorxiv.org
Type VI CRISPR-Cas systems use the RNA-guided RNase Cas13 to defend bacteria against
viruses, and some of these systems encode putative membrane proteins that have unclear …
viruses, and some of these systems encode putative membrane proteins that have unclear …
Introduction of bifunctionality into the multidomain architecture of the ω-ester-containing peptide plesiocin
The modular biosynthetic pathway of ribosomally synthesized and post-translationally modified
peptides (RiPPs) enhances their engineering potential for exploring new structures and …
peptides (RiPPs) enhances their engineering potential for exploring new structures and …
Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
UJ Jung, MK Lee, YB Park, MA Kang… - The international journal of …, 2006 - Elsevier
Flavonoids have been identified as the antidiabetic components in a number of traditional
ethnic remedies. However, the mechanisms whereby these compounds exert their …
ethnic remedies. However, the mechanisms whereby these compounds exert their …