LRRK2 Parkinson disease mutations enhance its microtubule association

…, D Boassa, CCY Ho, HJ Rideout, J Hu… - Human molecular …, 2012 - academic.oup.com
Dominant missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common
genetic causes of Parkinson disease (PD) and genome-wide association studies identify …

Evaluation of defatted black soldier fly (Hermetia illucens L.) larvae meal as an alternative protein ingredient for juvenile Japanese seabass (Lateolabrax japonicus) …

G Wang, K Peng, J Hu, C Yi, X Chen, H Wu, Y Huang - Aquaculture, 2019 - Elsevier
Defatted black soldier fly larvae meal (DBSFLM) has been shown a promising fish meal (FM)
substitute in diets for turbot, rainbow trout, Jian carp, Pacific white shrimp and Atlantic …

Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for …

…, ML Berlanga, MA Yang, M Terada, J Hu… - Journal of …, 2013 - Soc Neuroscience
Modifications to the gene encoding human α-synuclein have been linked to the development
of Parkinson's disease. The highly conserved structure of α-synuclein suggests a functional …

Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K–and Vav-dependent pathway, but does not absolutely require phospholipase C

M Villalba, K Bi, J Hu, Y Altman, P Bushway… - The Journal of cell …, 2002 - rupress.org
PKCθ plays an essential role in activation of mature T cells via stimulation of AP-1 and NF-κB,
and is known to selectively translocate to the immunological synapse in antigen-…

[HTML][HTML] High-quality ultrastructural preservation using cryofixation for 3D electron microscopy of genetically labeled tissues

TK Tsang, EA Bushong, D Boassa, J Hu, B Romoli… - Elife, 2018 - ncbi.nlm.nih.gov
Electron microscopy (EM) offers unparalleled power to study cell substructures at the nanoscale.
Cryofixation by high-pressure freezing offers optimal morphological preservation, as it …

Effects of substitution of fish meal with black soldier fly (Hermetia illucens) larvae meal, in yellow catfish (Pelteobagrus fulvidraco) diets

J Hu, G Wang, Y Huang, Y Sun, F He, H Zhao, N Li - 2017 - evols.library.manoa.hawaii.edu
An 8-week feeding trial was conducted to evaluate effects of replacing fish meal (FM) with
black soldier fly larvae meal (BSF) on growth performance, feed utilization, and plasma …

SPAK kinase is a substrate and target of PKCθ in T‐cell receptor‐induced AP‐1 activation pathway

Y Li, J Hu, R Vita, B Sun, H Tabata, A Altman - The EMBO journal, 2004 - embopress.org
Protein kinase C‐θ (PKCθ) plays an important role in T‐cell activation via stimulation of AP‐1
and NF‐κB. Here we report the isolation of SPAK, a Ste20‐related upstream mitogen‐…

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

…, D Boassa, S Mathea, S Silletti, J Hu… - Proceedings of the …, 2021 - National Acad Sciences
To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2 (LRRK2)
hijack its finely tuned activation process and drive Parkinson’s disease (PD), we used a …

Evaluation of defatted Hermetia illucens larvae meal for Litopenaeus vannamei: effects on growth performance, nutrition retention, antioxidant and immune response …

G Wang, K Peng, J Hu, W Mo, Z Wei… - Aquaculture …, 2021 - Wiley Online Library
Defatted black soldier fly (Hermetia illucens) larvae meal (DBSFLM) has been shown an
important alternative protein ingredient for fish, but little information is available about the effect …

[HTML][HTML] Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane

D Boassa, P Nguyen, J Hu, MH Ellisman… - Frontiers in cellular …, 2015 - frontiersin.org
Pannexin2 (Panx2) is the largest of three members of the pannexin proteins. Pannexins are
topologically related to connexins and innexins, but serve different functional roles than …