Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in
mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the …

In response to DNA damage or replication fork stress, the Fanconi anemia pathway is
activated, leading to monoubiquitination of FANCD2 and FANCI and their colocalization in foci. …

Mammalian HELQ is a 3′–5′ DNA helicase with strand displacement activity. Here we
show that HELQ participates in a pathway of resistance to DNA interstrand crosslinks (ICLs). …

To exploit vulnerabilities of tumors, it is urgent to identify associated defects in genome
maintenance. One unsolved problem is the mechanism of regulation of DNA double‐strand break …

The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic
stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is …

When a replicative DNA polymerase (Pol) is stalled by damaged DNA, a “polymerase switch”
recruits specialized translesion synthesis (TLS) DNA polymerase(s) to sites of damage. …

ATR kinase activates the S-phase checkpoint when replication forks stall at sites of DNA
damage. This event also causes phosphorylation of the Fanconi anemia (FA) protein FANCI, …

R‐loops, which consist of DNA : RNA hybrids and displaced single‐strand DNA , are a major
threat to genome stability. We have previously reported that a key Fanconi anemia protein, …

DNA polymerase zeta (pol ζ) is exceptionally important for controlling mutagenesis and genetic
instability. REV3L comprises the catalytic subunit, while REV7 (MAD2L2) is considered …

When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated
in the cell to halt cell cycle progression and promote DNA repair. A pathway initiated by the …