Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

We propose a network representation of electrically coupled beta cells in islets of Langerhans.
Beta cells are functionally connected on the basis of correlations between calcium …

In endocrine cells within islets of Langerhans calcium ions couple cell stimulation to hormone
secretion. Since the advent of modern fluorimetry, numerous in vitro studies employing …

In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is coupled
to secretion of insulin through different intracellular signaling pathways. Our knowledge …

Oscillatory electrical activity is regarded as a hallmark of the pancreatic beta cell glucose-dependent
excitability pattern. Electrophysiologically recorded membrane potential oscillations …

Collective beta cell activity in islets of Langerhans is critical for the supply of insulin within an
organism. Even though individual beta cells are intrinsically heterogeneous, the presence …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

The release of peptide hormones is predominantly regulated by a transient increase in cytosolic
Ca 2+ concentration ([Ca 2+ ] c ). To trigger exocytosis, Ca 2+ ions enter the cytosol from …

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients,
and impaired insulin secretion plays a central role in development of diabetes mellitus. …