… Data analysis and interpretation: Justin F. Creeden, Zachary A. Kipp, Khaled Alganem,
Ali S. Imami, Robert M. … Creeden. Manuscript review and revisions: Terry D. Hinds, Jr., …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Homologous recombination and DNA repair are important for genome maintenance. Genetic
variations in essential homologous recombination genes, including BRCA1 and BRCA2 …

Hyperinflammatory response caused by infections such as Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) increases organ failure, intensive care unit admission, …

CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering
therapeutics. The limited understanding of the mechanisms driving these illnesses with the slow …

Oxidative stress, a condition characterized by an imbalance between pro-oxidant molecules
and antioxidant defense systems, is increasingly recognized as a key contributor to cancer …

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted
the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide
pandemic, infecting over 16 million people worldwide with a significant mortality rate. …

Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus protective …

The leading cause of death in patients with nonalcoholic fatty liver disease (NAFLD) is
cardiovascular disease (CVD). However, the mechanisms are unknown. Mice deficient in …