Accurate inference of regulatory networks from experimental data facilitates the rapid
characterization and understanding of biological systems. High-throughput technologies can …

Liquid biopsy is a valuable precision oncology tool that is increasingly used as a non-invasive
approach to identify biomarkers, detect resistance mutations, monitor disease burden, and …

PURPOSE Tissue-based next-generation sequencing (NGS) in metastatic breast cancer (mBC)
is limited by the inability to noninvasively track tumor evolution. Cell-free DNA (cfDNA) …

During mitosis, centrosomes serve as microtubule organizing centers that guide the formation
of a bipolar spindle. However, oocytes of many species lack centrosomes; how meiotic …

An organism’s ability to maintain a desired physiological response relies extensively on how
cellular and molecular signaling networks interpret and react to environmental cues. The …

Motivation To understand the regulatory pathways underlying diseases, studies often
investigate the differential gene expression between genetically or chemically differing cell …

Cells are complex, autonomous machines that integrate many environmental cues to execute
a desired response. Though this property makes cells versatile, it presents significant …

There have been many achievements in applying biochemical synthetic routes to the synthesis
of commodity chemicals. However, most of these endeavors have focused on optimizing …

Background Many patients experience local recurrence or metastases after receiving potentially
curative treatment, and early detection of these events is important for disease control. …

Having been a professor at the university level for over thirty years, I want to share with
everyone in the world the knowledge I have learned about one of the most successful …