This article systematically reviews the research design and methodological characteristics
of single-case experimental design (SCED) research published in peer-reviewed journals …

Background Numerous models, frameworks, and theories exist for specific aspects of
implementation research, including for determinants, strategies, and outcomes. However, …

The emergence and persistence of conduct problems (CPs) during early childhood is a
robust predictor of behavior problems in school and of future maladaptation. In this study we …

Childhood obesity has become a global pandemic in developed countries, leading to a host
of medical conditions that contribute to increased morbidity and premature death. The …

Background Genome-scale CRISPR interference (CRISPRi) has been used in human cell
lines; however, the features of effective guide RNAs (gRNAs) in different organisms have not …

US health care systems are tasked with alleviating the burden of mental health, but are
frequently underprepared and lack workforce and resource capacity to deliver services to all in …

A major challenge in genetics is to identify genetic variants driving natural phenotypic variation.
However, current methods of genetic mapping have limited resolution. To address this …

This article provides new reflections and recommendations from authors of the initial
effectiveness-implementation hybrid study manuscript and additional experts in their …

Our understanding of how genotype controls phenotype is limited by the scale at which we
can precisely alter the genome and assess the phenotypic consequences of each …

Background Transcriptional reprogramming is a fundamental process of living cells in order
to adapt to environmental and endogenous cues. In order to allow flexible and timely control …