Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and
drug responses. To resolve inconsistencies among the reported gene expression–based CRC …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life. …

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

Background Gene set enrichment (GSE) analysis is a popular framework for condensing
information from gene expression profiles into a pathway or signature summary. The strengths …

The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the 'one gene, one drug' paradigm of …

Objective Coronavirus disease 2019 (COVID-19) poses societal challenges that require
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

Importance The National COVID Cohort Collaborative (N3C) is a centralized, harmonized,
high-granularity electronic health record repository that is the largest, most representative …

Tag sequencing using high-throughput sequencing technologies are now regularly
employed to identify specific sequence features, such as transcription factor binding sites (ChIP-seq) …