The anatomy of the mammalian visual system, from the retina to the neocortex, is organized
hierarchically 1 . However, direct observation of cellular-level functional interactions across …

Cortical circuits can flexibly change with experience and learning, but the effects on specific
cell types, including distinct inhibitory types, are not well understood. Here we investigated …

The mammalian visual system, from retina to neocortex, has been extensively studied at
both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is …

Quickly and flexibly exploring high-dimensional datasets, such as scRNAseq data, is
underserved but critical for hypothesis generation, dataset annotation, publication, sharing, and …

Neurodata Without Borders: Neurophysiology (NWB:N) is a data standard for neurophysiology,
providing neuroscientists with a common standard to share, archive, use, and build …

The detection of novel stimuli is critical to learn and survive in a dynamic environment. Though
novel stimuli powerfully affect brain activity, their impact on specific cell types and circuits …

To study the mechanisms of perception and cognition, neural measurements must be made
during behavior. A goal of the Allen Brain Observatory is to map the activity of distinct cortical …

The exploding field of single cell transcriptomics has begun to enable deep analysis of gene
expression and cell types, but spatial context is lost in the preparation of tissue for these …

One longstanding impediment to progress in understanding the neural basis of language is
the development of model systems that retain language-relevant cognitive behaviors yet …

Spike timing dependent plasticity is a critical component of long term synaptic changes that
seem to account for Hebbian-type learning and relies in many cases on backpropagating …