Clinical evidence suggests that rapid and sustained antidepressant action can be attained
with a single exposure to psychedelics. However, the biological substrates and key mediators …

Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their
effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity. Although
class A GPCRs are capable of activating G proteins in a monomeric form, they can also …

Previous studies demonstrate an association between activation of the maternal immune
system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, …

Antipsychotic drugs, including both typical such as haloperidol and atypical such as clozapine,
remain the current standard for schizophrenia treatment. These agents are relatively …

Alcohol use disorder is a major cause of morbidity, which requires newer treatment
approaches. We previously showed in a randomized clinical trial that alcohol craving and …

Background Prepulse inhibition (PPI) of startle is a sensorimotor gating phenomenon perturbed
in a variety of neuropsychiatric conditions. Psychedelics disrupt PPI in rats and humans, …

Prenatal environmental insults increase the risk of neurodevelopmental psychiatric
conditions in the offspring. Structural modifications of dendritic spines are central to brain …

Background Serotonin 5-HT 2A and metabotropic glutamate 2 (mGlu2) are neurotransmitter
G protein-coupled receptors (GPCRs) involved in the signaling mechanisms underlying …

Animal models of schizophrenia constitute at this moment fundamental experimentation tools
to further explore on the etiological basis of this pathology, leading to the discovery of new …