Innate immunity is the primary and most ancient defense against infection. Although critical to
survival, coordinating protection against a foreign organism is energetically costly, creating …

There is widespread agreement that science, technology, engineering, and mathematics
programs should provide undergraduates with research experience. Practical issues and …

A phylogenetically conserved response to nutritional abundance is an increase in insulin
signaling, which initiates a set of biological responses dependent on the species. …

Circadian rhythms are regulated by a synchronized system of central and peripheral clocks.
Here, we show that a clock in the Drosophila fat body drives rhythmic expression of genes …

In their 2012 report, the President's Council of Advisors on Science and Technology advocated
“replacing standard science laboratory courses with discovery-based research courses”…

Sleep length and metabolic dysfunction are correlated, but the causal relationship between
these processes is unclear. Octopamine promotes wakefulness in the fly by acting through …

Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep
loss is associated with increased appetite and insulin insensitivity, while chronically sleep…

Study Objectives Dysregulation of sleep is associated with metabolic diseases, and metabolic
rate (MR) is acutely regulated by sleep-wake behavior. In humans and rodent models, …

A hallmark of the research experience is encountering difficulty and working through those
challenges to achieve success. This ability is essential to being a successful scientist, but …

During nutrient excess, triglycerides are synthesized and stored to provide energy during times
of famine. The presence of high glucose leads to the activation of carbohydrate response …