The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

SapB is a morphogenetic peptide that is important for aerial mycelium formation by the
filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial …

Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and
for many other medicinal applications. The mechanisms that limit the production of these …

10.7554/eLife.21738.001 It has long been thought that the life cycle of Streptomyces bacteria
encompasses three developmental stages: vegetative hyphae, aerial hyphae and spores. …

The arms race between bacteria and the phages that infect them drives the continual evolution
of diverse anti-phage defences. Previously described anti-phage systems have highly …

Antiterminator proteins control gene expression by recognizing control signals near the
promoter and preventing transcriptional termination which would otherwise occur at sites that …

Many microorganisms produce molecules having antibiotic activity and expel them into the
environment, presumably enhancing their ability to compete with their neighbours. Given that …

The available literature on the secondary or nonessential metabolites of the streptomycetes
bacteria suggests that there may be poorly expressed or “cryptic” compounds that have yet …

Diverse bacterial species produce extracellular contractile injection systems (eCISs). Although
closely related to contractile phage tails, eCISs can inject toxic proteins into eukaryotic …

Antibiotic‐producing bacteria encode antibiotic resistance genes that protect them from the
biologically active molecules that they produce. The expression of these genes needs to …