User profiles for Justin Stebbing
Justin StebbingImperial College Verified email at imperial.ac.uk Cited by 33241 |
Baricitinib as potential treatment for 2019-nCoV acute respiratory disease
…, A Phelan, M Rawling, E Savory, J Stebbing - The lancet, 2020 - thelancet.com
Given the scale and rapid spread of the 2019 novel coronavirus (2019-nCoV) acute respiratory
disease, there is an immediate need for medicines that can help before a vaccine can be …
disease, there is an immediate need for medicines that can help before a vaccine can be …
[HTML][HTML] COVID-19: combining antiviral and anti-inflammatory treatments
J Stebbing, A Phelan, I Griffin, C Tucker… - The Lancet Infectious …, 2020 - thelancet.com
The Lancet, 3 we described how BenevolentAI’s proprietary artificial intelligence (AI)-derived
knowledge graph, 4 queried by a suite of algorithms, enabled identification of a target and …
knowledge graph, 4 queried by a suite of algorithms, enabled identification of a target and …
Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data
…, D Generali, JA Garcia-Saenz, J Stebbing… - The lancet …, 2014 - thelancet.com
Background We aimed to assess the clinical validity of circulating tumour cell (CTC) quantification
for prognostication of patients with metastatic breast cancer by undertaking a pooled …
for prognostication of patients with metastatic breast cancer by undertaking a pooled …
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients
J Stebbing, V Krishnan, S de Bono… - EMBO molecular …, 2020 - embopress.org
Baricitinib is an oral Janus kinase ( JAK )1/ JAK 2 inhibitor approved for the treatment of
rheumatoid arthritis ( RA ) that was independently predicted, using artificial intelligence ( AI ) …
rheumatoid arthritis ( RA ) that was independently predicted, using artificial intelligence ( AI ) …
[HTML][HTML] PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction
network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. …
network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. …
[PDF][PDF] Highly active antiretroviral therapy and the incidence of non–AIDS-defining cancers in people with HIV infection
T Powles, D Robinson, J Stebbing, J Shamash… - Journal of Clinical …, 2009 - Citeseer
… Thomas Powles, David Robinson, Justin Stebbing, Jonathan Shamash, Mark Nelson, Brian
Gazzard, Sundhiya Mandelia, Henrik Møller, and Mark Bower … Justin Stebbing, Jonathan …
Gazzard, Sundhiya Mandelia, Henrik Møller, and Mark Bower … Justin Stebbing, Jonathan …
The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response
…, J Waxman, GJ Hannon, J Stebbing - Proceedings of the …, 2009 - National Acad Sciences
Following estrogenic activation, the estrogen receptor-α (ERα) directly regulates the
transcription of target genes via DNA binding. MicroRNAs (miRNAs) modulated by ERα have the …
transcription of target genes via DNA binding. MicroRNAs (miRNAs) modulated by ERα have the …
Personalized detection of circulating tumor DNA antedates breast cancer metastatic recurrence
…, S Ahmed, S Ali, S Cleator, L Kenny, J Stebbing… - Clinical Cancer …, 2019 - AACR
Purpose: Up to 30% of patients with breast cancer relapse after primary treatment. There
are no sensitive and reliable tests to monitor these patients and detect distant metastases …
are no sensitive and reliable tests to monitor these patients and detect distant metastases …
Clinical characteristics and outcomes of COVID-19–infected cancer patients: a systematic review and meta-analysis
…, H Chen, V Velcheti, J Stebbing… - JNCI: Journal of the …, 2021 - academic.oup.com
Background Previous studies have indicated coronavirus disease 2019 (COVID-19) patients
with cancer have a high fatality rate. Methods We conducted a systematic review of studies …
with cancer have a high fatality rate. Methods We conducted a systematic review of studies …
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
J Stebbing, G Sánchez Nievas, M Falcone… - Science …, 2021 - science.org
Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show
a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-…
a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-…