Combined measurement of diverse molecular and anatomical traits that span multiple levels
remains a major challenge in biology. Here, we introduce a simple method that enables …

The biology of multicellular organisms is coordinated across multiple size scales, from the
subnanoscale of molecules to the macroscale, tissue-wide interconnectivity of cell populations…

Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures
resembling the developing human brain. These three-dimensional models offer an …

Studying the function and dysfunction of complex biological systems necessitates comprehensive
understanding of individual cells. Advancements in three-dimensional (3D) tissue …

Cataracts is a serious eye disease, affecting over 20 million people worldwide. It is the clouding
of the lens, which blocks the light to go through the lens and project on the retina [1]. As …

Here we describe an image processing pipeline for quantitative analysis of terabyte-scale
volumetric images of SHIELD-processed mouse brains imaged with light-sheet microscopy. …

… The first author is grateful for the supervision of Justin M. Swaney during the summer research
program and is thankful to Dr. Evan Patton for his thoughtful comments that helped guide …

Rett Syndrome (RTT) is a pervasive, X-linked neurodevelopmental disorder that predominantly
affects girls. It is mostly caused by a sporadic mutation in the gene encoding methyl CpG-…

The brain is the most complex human organ, containing components from the nanometer
scale to the centimeter scale However, many experimental techniques in neuroscience have …

6.1 Summary Cerebral organoids grown from patient-derived stem cells self-pattern into
cytoarchitectures mimicking the developing human cortex These 3D models offer an …