While long non-coding RNA (lncRNA) research in the past has primarily focused on the
discovery of novel genes, today it has shifted towards functional annotation of this large class of …

Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are
derived almost exclusively from small and polyadenylated RNAs. Here we present a more …

Compromised RNA quality is suggested to lead to unreliable results in gene expression studies.
Therefore, assessment of RNA integrity and purity is deemed essential prior to including …

Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease.
Where most studies focus on blood-derived fluids, other biofluids may be more informative. …

RNA profiling has emerged as a powerful tool to investigate the biomarker potential of
human biofluids. However, despite enormous interest in extracellular nucleic acids, RNA …

The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA
sequencing data processed using computational tools. Numerous such tools have been …

Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression
profiles, making them highly attractive as therapeutic targets. Pan-cancer RNA sequencing …

While cell-free DNA (cfDNA) is widely being investigated, free circulating RNA (extracellular
RNA, exRNA) has the potential to improve cancer therapy response monitoring and …

Circulating nucleic acids in blood plasma form an attractive resource to study human health
and disease. Here, we applied mRNA capture sequencing of blood plasma cell-free RNA …

The use of blood-based extracellular RNA (cell-free RNA; exRNA) as clinical biomarker
requires the implementation of a validated procedure for sample collection, processing, and …