SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and
2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in …

Background Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell
communication structures promoting invasion and treatment resistance through network …

Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10%
in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and …

Lactate is a central metabolite in brain physiology but also contributes to tumor development.
Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, …

Background: The aim of this study was to assess the efficacy of neoadjuvant anastrozole
and fulvestrant treatment of large operable or locally advanced hormone-receptor-positive …

Background Glioblastomas are heterogeneous tumors composed of a necrotic and tumor
core and an invasive periphery. Methods Here, we performed a proteomics analysis of laser-…

Basal-like breast cancers are among the most aggressive cancers and effective targeted
therapies are still missing. In order to identify new therapeutic targets, we performed Methyl-Seq …

The glucose-requiring hexosamine biosynthetic pathway (HBP), which produces UDP-N-acetylglucosamine
for glycosylation reactions, promotes lung adenocarcinoma (LUAD) …

We have previously tested biopsies from 1469 breast tumours with a p53 functional assay in
the context of a prospective clinical trial ( EORTC 10994/ BIG 1–00). The goal of the trial …

Targeted sequencing is commonly used in clinical application of NGS technology since it
enables generation of sufficient sequencing depth in the targeted genes of interest and thus …