Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of
early childhood characterized by mutations activating RAS signaling. Established clinical and …

Deregulated transcriptional control caused by aberrant DNA methylation and/or histone
modifications is a hallmark of cancer cells. In chronic lymphocytic leukemia (CLL), the most …

A-kinase anchor protein 12 (AKAP12) is a regulator of protein kinase A and protein kinase
C signaling, acting downstream of RAS. Epigenetic silencing of AKAP12 has been …

Recurrent translocations are common in acute myeloid leukemia (AML) and important for
cytogenetic classification and prognosis [1]. AML-derived leukemic cell lines have been …

Background In cancer, normal epigenetic patterns are disturbed and contribute to gene
expression changes, disease onset, and progression. The cancer epigenome is composed of the …

Ultraviolet radiation B stimulates both the production of vitamin D 3 in the skin and the activation
of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central …

Interleukin 33 (IL-33) belongs to the IL-1 family and is produced constitutively by epithelial
and endothelial cells of various organs, such as the skin. It takes part in the maintenance of …

Regardless of the recent groundbreaking introduction of personalized therapy, melanoma
continues to be one of the most lethal skin malignancies. Still, a substantial proportion of …

It is well established, that epidermal keratinocytes express functional equivalent of
hypothalamus–pituitary–adrenal axis (HPA) in order to respond to changing environment and …

The genomic activity of 1,25(OH) 2 D 3 is mediated by vitamin D receptor (VDR), whilst non-genomic
is associated with protein disulfide isomerase family A member 3 (PDIA3). …