Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

Chromosome segregation and cell division are essential, highly ordered processes that depend
on numerous protein complexes. Results from recent RNA interference screens indicate …

Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial
proteomics, a key challenge remains connecting images with single-cell-resolution protein …

To understand the function of cellular protein networks, spatial and temporal context is essential.
Fluorescence correlation spectroscopy (FCS) is a single-molecule method to study the …

Quantitative microscopy relies on imaging of large cell numbers but is often hampered by
time-consuming manual selection of specific cells. The 'Micropilot' software automatically …

During animal cell division, an actin-based ring cleaves the cell into two. Problems with this
process can cause chromosome missegregation and defects in cytoplasmic inheritance and …

Solid-phase reverse transfection on cell microarrays is a high-throughput method for the
parallel transfection of mammalian cells. However, the cells transfected in this way have been …

The systems-wide analysis of biomolecules in time and space is key to our understanding of
cellular function and heterogeneity in health and disease 1 . Remarkable technological …

Isoform E2 of drebrin, an actin-binding protein originally identified in neuronal cells, has
recently been identified in diverse non-neuronal cells, mostly in association with cell processes …

The actin-binding protein (ABP) drebrin, isoform E2, is involved in remodelling of the actin
cytoskeleton and in formation of cell processes, but its role in cell migration has not yet been …