User profiles for Jyotirmoy Rakshit

Jyotirmoy Rakshit

University of Texas Health, Houston
Verified email at uth.tmc.edu
Cited by 182

Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid

K Patra, S Bose, S Sarkar, J Rakshit, S Jana… - Chemico-biological …, 2012 - Elsevier
Cinnamic acid (C 9 H 8 O 2 ), is a major constituent of the oriental Ayurvedic plant Cinnamomum
cassia (Family: Lauraceae). This phenolic acid has been reported to possess various …

An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

…, O Sahay, S Roy, AR Sinha, H Adicherla, J Rakshit… - Science …, 2023 - science.org
Sensing of pathogens by ubiquitination is a critical arm of cellular immunity. However, universal
ubiquitination targets on microbes remain unidentified. Here, using in vitro, ex vivo, and …

[PDF][PDF] Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury

…, RCD Duran, S Singh, LS Chaboub, J Rakshit… - Cell reports, 2023 - cell.com
Recent studies have revealed the heterogeneous nature of astrocytes; however, how diverse
constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury and …

Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: implication in Alzheimer's disease therapeutics

S Chakraborty, J Rakshit, J Bandyopadhyay… - International Journal of …, 2021 - Elsevier
The polygenic nature of Alzheimer's disease (AD) and cross-talk between several signaling
cascades make it harder to decode the disease pathogenesis. β-secretase (BACE1) works …

Iron-induced apoptotic cell death and autophagy dysfunction in human neuroblastoma cell line SH-SY5Y

J Rakshit, A Mallick, S Roy, A Sarbajna, M Dutta… - … Trace Element Research, 2020 - Springer
Iron accumulation plays a major role in neuronal cell death which has severe effects on
mental health like neurodegenerative disorders. The present work aims to explore the …

Anti HIV-1 and antimicrobial activity of the leaf extracts of Calotropis procera

R Mohanraj, J Rakshit, M Nobre - International Journal of …, 2010 - greenpharmacy.info
Calotropis procera R. Br.(Asclepiadiaceae) is an important medicinal plant whose leaves
and roots have multiple uses. The plant is a rich source of many bioactive compounds which …

Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction

J Rakshit, A Priyam, KK Gowrishetty, S Mishra… - Journal of Trace …, 2020 - Elsevier
Background Intracellular iron involves in Fenton’s reaction-mediated Hydroxyl radical (OH·)
generation by reacting with the neurotoxic agent 6-Hydroxydopamine (6-OHDA) …

Multi-functional neuroprotective activity of neohesperidin dihydrochalcone: a novel scaffold for Alzheimer's disease therapeutics identified via drug repurposing …

S Chakraborty, J Rakshit, J Bandyopadhyay… - New Journal of …, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is a complex neurological disorder where many pathogenic
signaling cascades are simultaneously activated. Moreover, their inter-relations and molecular …

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

…, S Bhutda, S Ghosh, K Sharma, O Sahay, J Rakshit… - bioRxiv, 2021 - biorxiv.org
Sensing of pathogens by ubiquitination is critical for maintaining cytosolic sanctity. However,
universal ubiquitination targets on bacteria, especially of proteinaceous origin, remain …

The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease.

H Wei, J Withrow, J Rakshit, FU Amin, J Nahm… - Aging and …, 2024 - europepmc.org
Alzheimer's disease (AD) is characterized by the presence of two hallmark pathologies: the
accumulation of Amyloid beta (Aβ) and tau proteins in the brain. There is a growing body of …