The 'neurotrophin hypothesis of depression' is based largely on correlations between stress
or antidepressant treatment and down- or upregulation, respectively, of brain-derived …

Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two
seemingly distinct signaling systems that play regulatory roles in many neuronal functions …

Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent episodes of
mania and depression. In addition to these cyclic episodes, individuals with BPD exhibit …

… MeCP2 can interact not only with HDACs but also with the histone H3 lysine (K) 9
methyltransferase, SUV39H1, and trigger dimethylation of histone H3 on K9 (H3 dm K9), providing a …

Despite its increasing use in experimental and clinical settings, the cellular and molecular
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown. …

DNA methylation is a major epigenetic factor that has been postulated to regulate cell lineage
differentiation. We report here that conditional gene deletion of the maintenance DNA …

We used the 10x Genomics Visium platform to define the spatial topography of gene expression
in the six-layered human dorsolateral prefrontal cortex. We identified extensive layer-…

The subgranular zone of the adult hippocampal dentate gyrus contains a pool of neural
stem cells that continuously divide and differentiate into functional granule cells. It has been …

… Purified bacterially expressed tyrosine-phosphorylated STAT1 was obtained from K. Shuai
49 . … Herschman and K. Shuai at UCLA for critical reading of the manuscript and providing …

Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …