Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—ischemia—and
then restored—reperfusion—leading to a burst of reactive oxygen species (ROS) …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

Mice xenotransplanted with human cells and/or expressing human gene products (also known
as “humanized mice”) recapitulate the human evolutionary specialization and diversity of …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …

Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …

Despite their crucial role in health and disease, our knowledge of immune cells within human
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …

… j, k, Substitutions (j) and indels (k) per cell in smooth muscle from 10 donors spanning
different ages (n = 2 libraries for donors aged 54 and 68 years). l, m, Substitution (l) and indel (m) …