Abstract Comparison of DNA sequences from different species is a fundamental method for
identifying functional elements in genomes. Here, we describe the VISTA family of tools …

Global patterns of human DNA sequence variation (haplotypes) defined by common single
nucleotide polymorphisms (SNPs) have important implications for identifying disease …

Individual differences in DNA sequence are the genetic basis of human variability. We have
characterized whole-genome patterns of common human DNA variation by genotyping …

The last few years have seen extensive efforts to catalogue human genetic variation and
correlate it with phenotypic differences. Most common SNPs have now been assessed in …

PipMaker ( http://bio.cse.psu.edu ) is a World-Wide Web site for comparing two long DNA
sequences to identify conserved segments and for producing informative, high-resolution …

… Dubchak,I., Brudno,M., Pachter,LS, Loots,GG, Mayor,C., Rubin,EM and Frazer,KA (2000)
Active conservation of noncoding sequences revealed by 3-way species comparisons. …

Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer
1 , 2 , 3 , 4 , 5 . In response to pathogens or injury, inflammatory macrophages express …

Long-range regulatory elements are difficult to discover experimentally; however, they tend
to be conserved among mammals, suggesting that cross-species sequence comparisons …

There has been growing debate over the nature of the genetic contribution to individual
susceptibility to common complex diseases such as diabetes, osteoporosis, and cancer. The ‘…

The genomes of individuals from the same species vary in sequence as a result of different
evolutionary processes. To examine the patterns of, and the forces shaping, sequence …