User profiles for K. A. Lazarus
 | Kyren LazarusUCL Verified email at ucl.ac.uk Cited by 678 |
Therapeutic potential of liver receptor homolog-1 modulators
KA Lazarus, D Wijayakumara, AL Chand… - The Journal of steroid …, 2012 - Elsevier
Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily,
and plays vital roles in early development, cholesterol homeostasis, steroidogenesis …
and plays vital roles in early development, cholesterol homeostasis, steroidogenesis …
[HTML][HTML] Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter
NI Fleming, KC Knower, KA Lazarus, PJ Fuller… - PloS one, 2010 - journals.plos.org
Background Granulosa cell tumors (GCT) of the ovary often express aromatase and
synthesize estrogen, which in turn may influence their progression. Recently a specific point …
synthesize estrogen, which in turn may influence their progression. Recently a specific point …
[HTML][HTML] The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
…, A Poh, T Putoczki, RJ Morrow, M Alorro, KA Lazarus… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Drugs that target the Renin-Angiotensin System (RAS) have recently come into focus for
their potential utility as cancer treatments. The use of Angiotensin Receptor Blockers (ARBs) …
their potential utility as cancer treatments. The use of Angiotensin Receptor Blockers (ARBs) …
[HTML][HTML] Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
It is unclear how genetic aberrations impact the state of nascent tumour cells and their
microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise …
microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise …
[HTML][HTML] BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
KA Lazarus, F Hadi, E Zambon, K Bach… - Nature …, 2018 - nature.com
Patients diagnosed with lung squamous cell carcinoma (LUSC) have limited targeted therapies.
We report here the identification and characterisation of BCL11A, as a LUSC oncogene. …
We report here the identification and characterisation of BCL11A, as a LUSC oncogene. …
Transformation of naked mole-rat cells
The naked mole rat (NMR), Heterocephalus glaber, is a mouse-sized subterranean rodent
that is native to East Africa and is used in research for the potential development of …
that is native to East Africa and is used in research for the potential development of …
[HTML][HTML] The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation
…, KC Knower, KA Herridge, TL Howard, KA Lazarus… - PloS one, 2012 - journals.plos.org
Background Liver Receptor Homolog 1 (LRH-1, NR5A2) is an orphan nuclear receptor that
is over-expressed in cancers in tissues such as the breast, colon and pancreas. LRH-1 plays …
is over-expressed in cancers in tissues such as the breast, colon and pancreas. LRH-1 plays …
[PDF][PDF] Cell-intrinsic differences between human airway epithelial cells from children and adults
…, KHC Gowers, C Denais, S Gómez-López, KA Lazarus… - Iscience, 2022 - cell.com
The airway epithelium is a protective barrier that is maintained by the self-renewal and
differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases…
differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases…
What are Lazarus taxa?
E Fara - Geological Journal, 2001 - Wiley Online Library
… Lazarus effect as the temporary disappearance of taxa from the fossil record in any given time
interval, many others consider the Lazarus … the Lazarus pattern: either Lazarus taxa reflect …
interval, many others consider the Lazarus … the Lazarus pattern: either Lazarus taxa reflect …
Estradiol regulates Tumor Necrosis Factor-α expression and secretion in Estrogen Receptor positive breast cancer cells
SQ To, V Cheung, KA Lazarus, KC Knower… - Molecular and cellular …, 2014 - Elsevier
The cytokine Tumor Necrosis Factor-α is critical to Estrogen Receptor positive breast cancer
pathology, stimulating estrogen-biosynthesis pathways and preventing the differentiation of …
pathology, stimulating estrogen-biosynthesis pathways and preventing the differentiation of …