Creatine (Cr) is a guanidino compound required for rapid replenishment of ATP in cells with
a high-energy demand. In humans, mutations in the Cr transporter (CRT;SLC6A8) prevent …

Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations
of CrT. Aim: This work focus on the preclinical development of a new therapeutic approach …

Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X‐linked disorder characterized
by severe cognitive deficits, impairments in language and an absence of brain creatine (Cr). …

… In fact, the brain Cr levels in this study (3 to 5% of WT levels) were lower than the Cr levels
from the brain-specific Slc6a8 used in Udobi et al (20% of WT), suggesting that Cr levels were …

Creatine transporter (CrT) deficiency (CTD) is an X-linked disorder characterized by intellectual
disability and speech delay. There have been reports that show female carriers have …

The lack of cerebral creatine (Cr) causes intellectual disability and epilepsy. In addition, a
significant portion of individuals with Cr transporter (Crt) deficiency (CTD), the leading cause of …

The discovery of the creatine (Cr)-phosphocreatine (PCr) system has had profound impact
on the understanding of cellular bioenergetics, physiology and human pathology. Cr is …

The absence of the high-energy phosphate buffer creatine (Cr) in the brain leads to intellectual
disability (ID), language impairment and epilepsy. 1 There are currently 3 known causes …

Background Focused Assessment with Sonography for Trauma (FAST) is rapidly establishing
its place in the evaluation of blunt abdominal trauma. However, no prospective study …

The generation of oxygen radicals during leukocyte-endothelial cell interaction is considered
to represent one of the fundamental steps of microvascular injury following ischemia and …