Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …

Dental caries and periodontitis account for a vast burden of morbidity and healthcare
spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported …

… In an admixed population with K ancestral populations, we … K Ā1 components must take
the value 0. Then, conditional on the admixture proportions p, the correlation of components k, k …

We estimated local ancestry on the autosomes and X chromosome in a large US-based study
of 12,793 Hispanic/Latino individuals using the RFMix method, and we compared different …

Background Genetic factors that influence kidney traits have been understudied for low
frequency and ancestry-specific variants. Methods We combined whole genome sequencing (…

Background Prospective studies have suggested higher factor VIII (FVIII) levels are an
independent risk factor for coronary heart disease (CHD) and stroke. However, limited information…

When testing genotype–phenotype associations using linear regression, departure of the
trait distribution from normality can impact both Type I error rate control and statistical power, …

… a K-means clustering algorithm to classify children into four groups of predominantly AFR (K
AFR ), AMR (K AMR ), EUR (K … K AFR and K AMR children had worse 15-year survival than …

Alzheimer disease (AD) is the most common form of senile dementia, with high incidence late
in life in many populations including Caribbean Hispanic (CH) populations. Such admixed …

… The code used to perform this bioinformatics analysis can be found at Dora Zucko GitHub
and the code for the circos plot at Grinde Lab GitHub last accessed: 31 January 2022 …