New validated cellular targets are needed to reinvigorate antibacterial drug discovery. This
need could potentially be filled by riboswitches—messenger RNA (mRNA) structures that …

… In addition, experiments in which two distal residues (40 Å apart) in helices I and II could be
covalently linked with a short crosslink (12 Å) without abolishing cleavage activity (KF Blount …

Riboswitches in messenger RNAs carry receptor domains called aptamers that can bind to
metabolites and control expression of associated genes. The Gram-positive bacterium …

Lysine riboswitches are bacterial RNA structures that sense the concentration of lysine and
regulate the expression of lysine biosynthesis and transport genes. Members of this …

Riboswitches are structured RNA domains that can bind directly to specific ligands and
regulate gene expression. These RNA elements are located most commonly within the …

Background Effective treatment options for recurrent Clostridioides difficile infection (rCDI)
are limited, with high recurrence rates associated with the current standard of care. Herein we …

The lack of high RNA target selectivity displayed by aminoglycoside antibiotics results from
both their electrostatically driven binding mode and their conformational adaptability. The …

Novel mechanisms of action and new chemical scaffolds are needed to rejuvenate antibacterial
drug discovery, and riboswitch regulators of bacterial gene expression are a promising …

… In 2001, Blount examined all the available literature that report cleavage of modified hammerheads
and only selected those results where the observed cleavage rate was likely to …

Aminoglycoside antibiotics such as neomycin (1a) and paromomycin (1b) bind to ribosomal
RNA (rRNA) at the decoding site and thereby interfere with the accuracy of protein synthesis, …