Entry into host macrophages and evasion of intracellular destruction mechanisms, including
phagosome-lysosome fusion, are critical elements of Mycobacterium tuberculosis (Mtb) …

Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms
regulating this dynamic process remain obscure. Here, we describe a phosphorylation…

The role of the serine/threonine kinase PknH in the physiology and virulence of Mycobacterium
tuberculosis was assessed by the construction of a pknH deletion mutant. Deletion of the …

The functions of OmpATb, the product of the ompATb gene of Mycobacterium tuberculosis
and a putative porin, were investigated by studying a mutant with a targeted deletion of the …

New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium
tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and …

Signal transduction in Mycobacterium tuberculosis is mediated primarily by the Ser/Thr protein
kinases and the two-component systems. The Ser/Thr kinase PknH has been shown to …

Intracellular pathogens such as Mycobacterium tuberculosis are able to survive in the face
of antimicrobial products generated by the host cell in response to infection. The product of …

An open reading frame in the genomic database ofMycobacterium tuberculosis H37Rv was
identified as having homology with an outer membrane protein. We found that the gene …

The ubiquitous and highly conserved RecA protein is generally expressed from a single
promoter, which is regulated by LexA in conjunction with RecA. We show here using …

A recA deletion mutant of Mycobacterium smegmatis has been isolated by homologous
recombination using a sacB counterselection strategy. Deletion of the recA gene from the …